|
T5374 |
NAcM-OPT
|
|
E1/E2/E3 Enzyme
,
NEDD8
|
|
NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 （IC50: 79 nM). |
|
T8816 |
NAE-IN-M22
|
NEDD8 inhibitor M22 |
Apoptosis
,
E1/E2/E3 Enzyme
|
|
NAE-IN-M22 (NEDD8 inhibitor M22) is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can i... |
|
T6332 |
Pevonedistat
|
MLN4924 |
E1/E2/E3 Enzyme
,
NEDD8
|
|
Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM). Pevonedistat can be used for the treatment of myelodysplastic syndromes (MDS) and also has antitumor activity. |
|
T13090 |
TAS4464 hydrochloride
|
|
E1/E2/E3 Enzyme
,
NEDD8
|
|
TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM). |
|
T13412 |
ZM223
|
ZM-223 |
E1/E2/E3 Enzyme
|
|
ZM223 is an inhibitor of NEDD8 activating enzyme (NAE). |
|
T16102 |
ML-792
|
|
E1/E2/E3 Enzyme
|
|
ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhi... |
|
T16117 |
Pevonedistat hydrochloride
|
MLN4924 hydrochloride |
Others
|
|
Pevonedistat hydrochloride is an effective and selective inhibitor of NEDD8-activating enzyme (IC50: 4.7 nM). |
|
T13090L |
TAS4464
|
|
E1/E2/E3 Enzyme
|
|
TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM). |
|
T13412L |
ZM223 hydrochloride (2031177-48-5 free base)
|
ZM223 hydrochloride |
Serine Protease
|
|
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of NEDD8 activating enzyme (NAE), and with excellent anticancer activity. |
